The correspondence in this collection begins in late 1947 while the Claxons awaited their ship to Africa, and the last letters were written from the United States following the Claxons' retirement as missionaries in 1981. The majority of the letters describe daily activities and missionary work in West Africa over a period of more than thirty years. The letters also include descriptions of the Claxon children's growth and activities, stories of the family's interactions with the peoples of Ghana, Nigeria and Benin, and discussions about the health and wellness of extended family. Frequent correspondents include Neville Claxon's mother, Frona, and sister, Eleanor, as well as children Carol Ann and William (Bill) Neville, Jr. following their return to the United States in pursuit of a college education.

Writings include those by Neville Claxon: brief travel narratives, summaries of experiences in Africa, and excerpts from a journal and daily calendar. There also is an account by an Assembly of God missionary, named McNutt, whose family lived near the Claxons when they first arrived in Kumasi, the Gold Coast, in June 1948.