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The Medieval and Renaissance mss., 700-1600, consists of individual items acquired from time to time either as a gift or purchased from a variety of sources.

The Miscellaneous mss., 2100 BCE-1970, consist of individual items acquired individually either as a gift or purchased from a variety of sources.

The Near Eastern mss., 700-1915, consist of a collection of individually acquired manuscripts pertaining to the region formerly known as the Near East, now referred to as the Middle East.

The Nelson's Encyclopedia mss., 1946-1947, consist of an article on penicillin by Sir Howard Florey, and several letters about the article between Florey, geneticist Hermann Muller, psychologist and Northwestern University president Walter Dill Scott, and science editor at Nelson's Encyclopedia Myron R. Kirsch.

The Noble, T.B. mss., 1957-1958, consist of papers of Dr. Thomas Benjamin Noble, 1895-1958, surgeon, of Indianapolis, Indiana.

The Rogers mss., 1851-1878, consist of manuscripts of Joseph Goodwin Rogers, 1841-1908, Indiana physician.

The Smith, H.W. mss., 1817-1987, consists of the letters of reformer Hannah Whitall Smith, 1832-1911, her daughters, art historian Mary Berenson, 1864-1945, and relief organizer Alys Whitall Pearsall Russell, 1867-1951, and her granddaughters, suffragist Ray Strachey, 1887-1940, and psychologist Karin Stephen, 1889–1953.

The Taylor, R. mss., 1804-1848, are typescripts of letters and papers of the Taylor family of Mason County, Kentucky, copied by Myra Esarey, Bloomington, Indiana, on July 7, 1917, from the originals loaned for that purpose by Frances Taylor of Hillsboro, Indiana.

The Tucker, W. D. mss., ca. 1863-1864, consist of a Confederate Army sword and scabbard; his inscribed copy of "(A) manual of military surgery, prepared for the use of the Confederate States Army," presented to him by Surgeon A.J. Foard, Medical Director of the Army of Tennessee; and a daguerreotype tintype of Tucker.

The Tuttle mss., 1838-1912, are papers of Elizabeth A. Tuttle, 1823?-1896, nurse and teacher of Colebrook, Ohio, and of Ira Norris Noland, 1844?- , physician, who married Hattie Tuttle, niece of Elizabeth A. Tuttle.