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The Ashton mss., 1818-1876, consists of the papers of textile designer William Adolphus Ashton, 1803-1870.

The Barnhart mss., 1813-1962, consists of the papers of history scholar John Donald Barnhart, 1895-1967.

The Bryan mss., 1849-1863, are chiefly the letters of George Washington Bryan, 1825-1893, physician, exchanged with his wife, Alice (Calhoun) Bryan, during his period of service in 1862-63 with the Union forces along the Mississippi River on the steamers Glasgow, the Tigress, the P. J. Pringle, and at Young's Point, Louisiana.

The Butler mss., 1835-1937, includes papers, 1877-1937, of Amos William Butler, 1860-1937, zoologist, anthropologist, and sociologist, and a few papers, 1835-1871, of his father, William Wallace Butler, 1810-1903, merchant and farmer.

Consists of the papers of Charles Willing Byrd. A member of the prominent Virginia family of that name, Byrd became deeply interested in the Shaker movement, and one of his sons, William Silonwe Byrd, joined the Shaker community at Pleasant Hill, Kentucky. For the years 1826-1828, a considerable portion of the collection consists of letters from this son, dealing with the beliefs of the Shakers and the affairs of Pleasant Hill. The collection also includes letters to Charles Willing Byrd from members of his family, in regard to family matters. Letters from an aunt refer to the death of Washington and to conditions in Philadelphia during the War of 1812. Some light on medical practices of the day is given in letters, 1826-1828, to Byrd from his physicians, prescribing treatment for him.

The Champ mss., 1836-1931, consists of the papers of Indiana physician, businessman, and postmaster George W. Champ, 1830-1905.

The Cookery mss., circa 1660–circa 1918, consists of bound and individual writings, often on the topic of cookery, of persons involved with cooking by practice or trade.

The Drake mss., 1848-1849, consists of the letters of physician Daniel Drake, 1785-1852, to his children, copied by U.S. senator Charles Daniel Drake, 1811-1892.

​The Evans mss., 1833-1873, consists of papers of Henry B. Evans, -1847?, physician and surgeon, of Marion County, Ind., and his heirs.

The Griffith mss., 1831-1881, consists of the papers of physician Thomas Jefferson Griffith, 1837-1924, and his wife, physician Martha Hutchings Griffith, 1842-1923.

The Holland mss., 1781-1953, consists of correspondence and papers of three generations of Holland family physicians from Bloomington, Indiana: Philip Calphy Holland, 1840-1929, his son, George Frank Holland, 1871-1936, and his son, Philip Todd Holland, 1905-1973.

The Houstoun mss., 1774-1799, consist of correspondence of Alexander Houstoun, ?-1784, physican, and correspondence of members of his family.

The Hunt mss., 1838-1845, consists of letters written by John Sloan, 1816-1898, physician of New Albany, Indiana, and his wife Caroline (Hunt) Sloan, 1810-1887, to Caroline's family in Maine, relating primarily to their emigration to Indiana.

The Indiana History mss., 1725-1973, consists of individual items related to the history of the state of Indiana, acquired separately either as a gift, purchase, transfer, or removal from a variety of sources.

The Kimball mss., 1828-1908, consists of the letters and papers of physician and soldier Nathan Kimball, 1822-1898.

The Latin American mss. --Mexico II, 1560-1940, consists of individual items acquired separately either as a gift, purchase, transfer, or removal from a variety of sources, complementing the materials in the Latin American mss. Mexico collection. Additions continue to be made.

The Latin American mss. Peru, 1535-1929, consist of over 6500 documents which trace the historical, economic and social development of what is presently known as Peru, with lesser coverage of Argentina, Bolivia, Chile and Ecuador.

The Leavitt mss., 1846-1849, consist of six letters from George C. Leavitt, 1824-1854, teacher and surveyor, to his parents in New Hampshire, and one letter from his wife Elizabeth to his parents.

The Maxwell mss., 1811-1852, consists of the papers of David Hervey Maxwell, 1786-1854, physician and trustee of Indiana University.

The McWhirter, Mrs. F.T. mss., 1840-1979, are papers of Luella Frances (Smith) McWhirter (Mrs. Felix Tony McWhirter), 1859-1952, clubwoman.

The Medieval and Renaissance mss., 700-1600, consists of individual items acquired from time to time either as a gift or purchased from a variety of sources.

The Miscellaneous mss., 2100 BCE-1970, consist of individual items acquired individually either as a gift or purchased from a variety of sources.

The Near Eastern mss., 700-1915, consist of a collection of individually acquired manuscripts pertaining to the region formerly known as the Near East, now referred to as the Middle East.

The Nelson's Encyclopedia mss., 1946-1947, consist of an article on penicillin by Sir Howard Florey, and several letters about the article between Florey, geneticist Hermann Muller, psychologist and Northwestern University president Walter Dill Scott, and science editor at Nelson's Encyclopedia Myron R. Kirsch.

The Noble, T.B. mss., 1957-1958, consist of papers of Dr. Thomas Benjamin Noble, 1895-1958, surgeon, of Indianapolis, Indiana.

The Rogers mss., 1851-1878, consist of manuscripts of Joseph Goodwin Rogers, 1841-1908, Indiana physician.

The Smith, H.W. mss., 1817-1987, consists of the letters of reformer Hannah Whitall Smith, 1832-1911, her daughters, art historian Mary Berenson, 1864-1945, and relief organizer Alys Whitall Pearsall Russell, 1867-1951, and her granddaughters, suffragist Ray Strachey, 1887-1940, and psychologist Karin Stephen, 1889–1953.

The Taylor, R. mss., 1804-1848, are typescripts of letters and papers of the Taylor family of Mason County, Kentucky, copied by Myra Esarey, Bloomington, Indiana, on July 7, 1917, from the originals loaned for that purpose by Frances Taylor of Hillsboro, Indiana.

The Tucker, W. D. mss., ca. 1863-1864, consist of a Confederate Army sword and scabbard; his inscribed copy of "(A) manual of military surgery, prepared for the use of the Confederate States Army," presented to him by Surgeon A.J. Foard, Medical Director of the Army of Tennessee; and a daguerreotype tintype of Tucker.

The Tuttle mss., 1838-1912, are papers of Elizabeth A. Tuttle, 1823?-1896, nurse and teacher of Colebrook, Ohio, and of Ira Norris Noland, 1844?- , physician, who married Hattie Tuttle, niece of Elizabeth A. Tuttle.

The U.S. History mss., 1612-1977, consist of individual items acquired separately either as a gift, purchase, transfer, or removal from a variety of sources, relating to the United States. Additions continue to be made.

The Wilder mss., 1860-1868, consist of letters to Edson Adelman Wilder, 1845-1927, hardware merchant of Orland, Indiana, from his friends and relatives serving in the 100th regiment, Co. B., of the Indiana Infantry.