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The Alströmer mss., 1779-1784 and 1865, consists of a series of French newsletters addressed in a number of instances to naturalist Clas Alströmer, 1736-1794, of Gothembourg, Sweden.

The American literature mss., 1789-2000, consists of an ongoing collection of individual items related to American literature.

The Blair, M.A.I. mss., 1684-1897, consists of letters and documents collected by art collector and benefactor Mary Anne Italia Mitchell Blair, 1855-1940.

The Cooper, M. mss., 1965-1992, consists primarily of letters and holiday cards from colonial historian, Charles Ralph Boxer, 1904-2000, to Jesuit author and editor Michael Cooper discussing writing projects of both men, mutual friends, activities and travels.

The Indiana History mss., 1725-1973, consists of individual items related to the history of the state of Indiana, acquired separately either as a gift, purchase, transfer, or removal from a variety of sources.

The King mss., 1815-1863, consists of the correspondence of Rufus King, 1755-1827, member of the Continental Congress and of the Constitutional Convention, U. S. senator and minister to Great Britain, and of members of his family.

The Lafayette mss. II, 1774-1957, are individual letters and documents relating to the Marquis de Lafayette, Marie Joseph Paul Yves Roch Gilbert du Motier, 1757-1834, general, which have been acquired from several sources.

The Mayhew mss., 1775-1782, consists of letters written to Betsy (also called Elizabeth or Eliza) Mayhew by Mary or Polly, sometimes referred to as Mary Palmer, 1746-1791.

The Meigs mss., 1794–1831, cpnsists of letters and papers of Return Jonathan Meigs, 1764–1825, governor of Ohio, United States senator, and postmaster general during the administrations of Presidents James Madison and James Monroe.

The Sharpe mss., 1733-1755, consists of papers from the office of John Sharpe, 1700-1756, London solicitor for the British West Indies, relating to the enforcement of the 1733 Molasses Act.

The Signers of the Declaration of Independence mss., 1848, consists of materials pertaining to the members of the Continental Congress who drafted and signed the Declaration of Independence.

The U.S. History mss., 1612-1977, consist of individual items acquired separately either as a gift, purchase, transfer, or removal from a variety of sources, relating to the United States. Additions continue to be made.

The Vernon mss., 1737-1740, consists of contemporary copies and extracts of the correspondence between Admiral Edward Vernon, 1684-1757, and the Great Britain Navy Board.

The Williams, Jonathan mss., 1738-1869, consist of letters and papers of Jonathan Williams, 1750-1815, merchant and soldier, grand-nephew of Benjamin Franklin and first superintendent of the U.S. Military Academy at West Point.