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The American literature mss., 1789-2000, consists of an ongoing collection of individual items related to American literature.

The Ames mss., 1840-1983 consist of the papers, correspondence, photographs, memorabilia and collected items of the Sally Mundy, 1886-1963, her son Richard Ames 1905-1984, and her second husband, author Talbot Mundy 1879-1940.

The Barnhart mss., 1813-1962, consists of the papers of history scholar John Donald Barnhart, 1895-1967.

The Bartholomew mss., 1838-1886, consists of the papers of American businessman, pioneer, and judicial officer Jacob Bartholomew, 1818-1863, and his wife, Emily Ebersole Bartholomew, 1825-1913.

The Baumgarten mss., 1957-1971, consist of the correspondence of literary agent Bernice Baumgarten, 1902-1978, with four women authors she represented over the years, as well as a file of general correspondence.

The Bloom mss., 1960-1973, consists of the letters of author Anaïs Nin, 1903-1977, to poet Roger Bloom, 1912-1979.

The Boone mss., 1791-1868, consists of the letters and papers of lawyer, teacher, merchant, and politician Benjamin Pennebaker Douglass, 1820-1904, and his second wife, Queen Victoria Boone, 1837-1885.

The Bowers mss. II, 1867-1960, consists of the papers of newspaperman and diplomat Claude Gernade Bowers, 1878-1958.

The Bowers mss. III, 1868-1972, consist of correspondence, speeches, writings, photographs, newspaper clippings, and memorabilia relating to Claude Gernade Bowers. The correspondence, dating from 1902-1972, is chiefly between members of the Bowers family, with almost five hundred letters from Sybil (McCaslin) Bowers to Claude Bowers before their marriage. Of particular interest are the letters of the 1930's written by Bowers to his daughter Patricia, giving information about personalities and events in Spain. There are also a number of letters from Holman Hamilton to Patricia Bowers.

The Brophy mss., 1962‑1979, consists of the correspondence and writings of British author Brigid Brophy, 1929‑1995.