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The Adomeit mss., 2000 BCE - 1995 CE, consists of miniature manuscripts collected by Ruth Elizabeth Adomeit, 1910-1996.

The Allen mss., 800-1972, consists of manuscript pieces collected by William Edward David Allen, 1901-1973, foreign service officer, businessman, and author, and his own writings about Georgian history.

The Alströmer mss., 1779-1784 and 1865, consists of a series of French newsletters addressed in a number of instances to naturalist Clas Alströmer, 1736-1794, of Gothembourg, Sweden.

The American literature mss., 1789-2000, consists of an ongoing collection of individual items related to American literature.

The Art mss., 1740-1993, consists of drawings, sketches, etchings, illustrations, and other works of art acquired individually from various artists.

The Astle mss., 1795-1797, consists of the letters and memoranda of Andrew Stuart, 1725-1801, Scottish lawyer, to Thomas Astle, 1735-1801, English antiquary and paleographer.

The Bingham, W. mss., 1752-1891, consist of the correspondence, writings, personal and business papers of American statesman William Bingham, 1752-1804.

The Binkley, Raglind mss., ca. 1450-1842, consist of medieval fragments collected by Thomas and Raglind Binkley.

The Binkley, Raglind mss., 1450-1842, consist of medieval fragments collected by lutenist Thomas Binkley, 1931-1995, and his wife, Raglind Herrel Binkley, 1940-.

The Blair, M.A.I. mss., 1684-1897, consists of letters and documents collected by art collector and benefactor Mary Anne Italia Mitchell Blair, 1855-1940.

The Boerner mss., 1779-1828, consist of manuscripts, journals, and correspondence by and relating to German writers Caroline von Wolzogen, Oskar Seidlin, and Friedrich von Schiller, along with related research material from German literary scholar and Goethe researcher Peter Boerner.

The Boone mss., 1791-1868, consists of the letters and papers of lawyer, teacher, merchant, and politician Benjamin Pennebaker Douglass, 1820-1904, and his second wife, Queen Victoria Boone, 1837-1885.

The Boxer mss. II, 1500-1938, consists of manuscripts and documents collected by colonial historian Charles Ralph Boxer, 1904-2000.

The Boxer mss. III, 1647-1999, consists of the correspondence, papers and memorabilia of historian Charles R. Boxer, 1904-2000.

Consists of the papers of Charles Willing Byrd. A member of the prominent Virginia family of that name, Byrd became deeply interested in the Shaker movement, and one of his sons, William Silonwe Byrd, joined the Shaker community at Pleasant Hill, Kentucky. For the years 1826-1828, a considerable portion of the collection consists of letters from this son, dealing with the beliefs of the Shakers and the affairs of Pleasant Hill. The collection also includes letters to Charles Willing Byrd from members of his family, in regard to family matters. Letters from an aunt refer to the death of Washington and to conditions in Philadelphia during the War of 1812. Some light on medical practices of the day is given in letters, 1826-1828, to Byrd from his physicians, prescribing treatment for him.

The Calverley mss., 1359-18/19th cent., consist of Arabic manuscripts collected by Edwin Elliott Calverley, 1882-1971, professor of Arabic and Islamic studies, whose notes about the documents are occasionally found inscribed thereon.

The Cookery mss., circa 1660–circa 1918, consists of bound and individual writings, often on the topic of cookery, of persons involved with cooking by practice or trade.

The Crame mss., 1774-1819, consists of the papers of brigadier general in the Spanish corps of engineers Agustín Crame, -1780.

The Draper mss., 1780-1854, consists of photostats of documents in the State Historical Society of Wisconsin, Madison, Wisconsin, assembled by historian Lyman Copeland Draper, 1815-1891.

The Dutilh mss., 1784-1811, consists of business letters in French to Dutilh and Wacksmuth, merchants of Philadelphia.