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The Brediman mss., 1626, consist of documents concerning Thomas Brediman, suspected of high treason and plotting against the King and the Duke of Buckingham.

The Scottish mss., 1500-1707, consists of materials concerned with the genealogies, history, letters, and writings of Scotland.

The Cassani mss., 1776-1777, consist of a logbook kept by navigator Francisco Cassani of the Santo Cristo del Calvario on its journey from Spain to Uruguay and Brazil.

The Boone mss., 1791-1868, consists of the letters and papers of lawyer, teacher, merchant, and politician Benjamin Pennebaker Douglass, 1820-1904, and his second wife, Queen Victoria Boone, 1837-1885.

The English History mss. is a miscellaneous collection of manuscripts in English history.

The Ege mss. II, 1240-1923, consists of Otto Ege's Original Leaves from Famous Books - Eight Centuries portfolio of leaves collected from books deemed historically significant.

The Aristotle mss., 1603-1704, consists of commentaries on the works of Aristotle. At least half of the volumes concentrate on logic, but other subjects are covered as well, including physics and general philosophy.

The Binkley, Raglind mss., ca. 1450-1842, consist of medieval fragments collected by Thomas and Raglind Binkley.

The Jonathan Krause Rare Newspaper and Magazine Collection consists of approximately 900 original issues of historical newspapers and magazines, with a focus on late 18th- and early 19th-century American publications.