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The Alex mss., 1910-1935, consists of letters from author Upton Beall Sinclair, 1890-1968, to lawyer and fellow socialist Tanna Alex, 1884-1982.

The Armour mss., 1952-1956, consists of letters from author Upton Sinclair, 1878-1968, to author and English professor Richard Willard Armour, 1906-1989.

The Boni mss., 1926-1939, consists of the correspondence of author Upton Beall Sinclair, 1878-1968, with publishers Albert Boni, 1892-1981, and Charles Boni, 1894-1969.

The Cane mss., 1936-1957, consist of letters from Upton Sinclair, 1878-1968, author, to Melville Henry Cane, 1879-, lawyer and poet. They relate in the main to Sinclair's writings.

The Colorado-Sinclair mss. consists of letters exchanged between author, Upton Beall Sinclair, 1878-1968, and University of Colorado Director of Libraries Eugene Holt Wilson, 1909-?, Boulder, Colorado, August 25-October 31, 1950.

The DeWitt mss., 1941-1955, consists of letters from Upton Sinclair, 1878-1968, author, to Samuel Aaron DeWitt, 1891-1963, poet and businessman, and correspondence between Mary Craig (Kimbrough) Sinclair, (Mrs. Upton Sinclair), 1883-1961, and DeWitt.

​The Eeden mss. consists of two reels, 1908-1913 and 1914-1918, of negative microfilm of letters and postcards of Upton Beall Sinclair, 1878-1968, novelist, to Frederik Willem van Eeden, 1860-1932, poet and dramatist, from the originals in the Frederik van Eeden-Genootschap at the University of Amsterdam in Amsterdam, Holland.

The Haldeman mss. III, 1915-1918, consists primarily of correspondence of Upton Beall Sinclair, 1878-1968, novelist, and Appeal to Reason staff members Louis Kopelin, 1887-1949, and Walter H. Wayland, 1884-1980.

The Howatt mss., 1902-1959, consist in the main of letters to David Howatt, 1882-1964 , farmer and secretary of Upton Beall Sinclair, from writers Harry Kemp, Upton Beall Sinclair, and William James Durant.

The Keller mss., 1938-1953, consists of letters and copies of letters from novelist Upton Beall Sinclair, 1878-1968, to clergyman and professor of theology Adolf Keller, 1872-1963.

The Koul mss., 1947-1953, consist of letters of Upton Beall Sinclair, 1878-1968, novelist, to Braj Kishan Koul of Agra, India, translator.

The Kus-Nikolajev mss., 1932-1957, are letters from Upton Beall Sinclair, 1878-1968, novelist, to Mirko Kus-Nikolajev, 1896-?, physician of Zagreb, Yugoslavia.

The Land mss., 1945-1953, consist of letters from Upton Beall Sinclair, 1878-1968, novelist, to translator Rene Land of Groningen, Holland.

The Lesser mss., 1933-1971, consist chiefly of the correspondence between Sol Lesser, 1890-1980, motion picture executive, and Upton Beall Sinclair, 1878-1968, novelist, and others concerned with their interests.

The Lush mss., 1956-1957, consists of two letters from Upton Beall Sinclair, 1878-1968, author, and a letter from Mrs. Mary Craig (Kimbrough) Sinclair, (Mrs. Upton Beall Sinclair), 1883-1961, author, to Samuel Beryl Lush, 1893?-?, cotton merchant.

The Saturday Review of Literature mss., 1946-1956, consists of letters from author Upton Sinclair, 1878-1968, to Norman Cousins, 1915-1990, and Harrison Smith, 1888-1971, editors of the Saturday Review of Literature.

The Sinclair mss. III, 1903-1904, consists of letters from novelist Upton Beall Sinclair, 1878-1968.

The Sinclair mss. V, 1902, consists of the application of novelist Upton Beall Sinclair, 1878-1968, for a fellowship in the Graduate School of Harvard University for the year 1902-1903.

The Sinclair mss. VII, 1923-1963, consists of letters and manuscripts by or about writer Upton Beall Sinclair, 1878-1968.

The Stokes mss., 1905-1906, consist primarily of letters from Upton Beall Sinclair, 1878-1968, novelist, to James Graham Phelps Stokes, 1872-1960, regarding the activities of the Intercollegiate Socialist Society.

The Viereck mss., 1943-1953, consists of typescripts of letters from novelist Upton Beall Sinclair, 1878-1968, to Peter Robert Edwin Viereck, 1916-2006, author and professor of history at Mount Holyoke College.

The Viking Press mss., 1940-1956, consists of the Viking Press office file of its correspondence with novelist Upton Beall Sinclair, 1878-1968.