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The Clark, W.A. mss., 1862-1918, consists primarily of letters from Hoosier soldier William Allen Clark, 1844- , to his parents in Rossville, Indiana, during his service in Company K of the 72nd Indiana Volunteer Infantry Regiment.

The Cleghorn mss., 1826-1893, consists of correspondence and papers of Indian trader William W. Cleghorn, 1815-1878, and material pertaining to his estate.

The Colfax mss., 1853-1884, consists of the papers of South Bend, Indiana, newspaperman, speaker of the House of Representatives, and vice-president of the United States Schuyler Colfax, 1823-1885.

The Holland mss., 1781-1953, consists of correspondence and papers of three generations of Holland family physicians from Bloomington, Indiana: Philip Calphy Holland, 1840-1929, his son, George Frank Holland, 1871-1936, and his son, Philip Todd Holland, 1905-1973.