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The Lewisohn mss., 1922-1937, consist of letters from literary men to Ludwig Lewisohn, 1883-1955, author and critic, and personal letters from Lewisohn to his wife, Mrs. Thelma (Spear) Lewisohn, and her mother, Mrs. Elias Spear.

The Ehrmann mss., 1899-1926, consists of letters to Max Ehrmann, 1872-1945, author, from Eugene Victor Debs, Frank Harris and Upton Beall Sinclair, and Mrs. A. Schember.

The Land mss., 1945-1953, consist of letters from Upton Beall Sinclair, 1878-1968, novelist, to translator Rene Land of Groningen, Holland.

The U.S. History mss., 1612-1977, consist of individual items acquired separately either as a gift, purchase, transfer, or removal from a variety of sources, relating to the United States. Additions continue to be made.

The Armour mss., 1952-1956, consists of letters from author Upton Sinclair, 1878-1968, to author and English professor Richard Willard Armour, 1906-1989.

The Baatz mss., 1940-2010, consists of correspondence from prominent literary and political figures to librarian Wilmer Henry Baatz, 1915-1991.

The Bowers mss. II, 1867-1960, consists of the papers of newspaperman and diplomat Claude Gernade Bowers, 1878-1958.

The Cane mss., 1936-1957, consist of letters from Upton Sinclair, 1878-1968, author, to Melville Henry Cane, 1879-, lawyer and poet. They relate in the main to Sinclair's writings.

The Clark mss., 1909-1957, consists of the letters and writings of author, editor, and publisher Thomas Curtis Clark, 1877-1953, as well as the autographs and poems of other writers collected by him.

The Alex mss., 1910-1935, consists of letters from author Upton Beall Sinclair, 1890-1968, to lawyer and fellow socialist Tanna Alex, 1884-1982.