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The Near Eastern mss., 700-1915, consist of a collection of individually acquired manuscripts pertaining to the region formerly known as the Near East, now referred to as the Middle East.

The Miscellaneous mss., 2100 BCE-1970, consist of individual items acquired individually either as a gift or purchased from a variety of sources.

The Adomeit mss., 2000 BCE - 1995 CE, consists of miniature manuscripts collected by Ruth Elizabeth Adomeit, 1910-1996.

The Appleton-Century mss., 1846-1962, consists of the office files of the publishing company, its two predecessors, D. Appleton & Co., and the Century Co., and to a small extent its successor, Appleton-Century Crofts, Inc.

The Hovey mss., 1841-1927, consist of letters and papers of Alvin Peterson Hovey, 1821-1891, governor of Indiana, and correspondence of his daughter, Mrs. Esther (Hovey) Menzies, and Mrs. Deidre Dorothy (Duff) Johnson.

The Huntington mss., 1841-1862, consist of the family correspondence of Elisha Mills Huntington, 1806-1862, Indiana lawyer and judge.

The Rumely mss., 1838-1965, are the papers of Edward Aloysius Rumely, 1882-1964, physician, educator, and public relations man, and papers relating to his ancestors. The papers consist of correspondence with prominent people both in Europe and the United States; an autobiography; documents dealing with his arrest for perjury in July, 1918, and the pardon by President Calvin Coolidge on January 19, 1925; material on his many fields of interest; pictures, and printed matter.

The Thompson mss., 1837-1899, are letters and papers of Richard Wigginton Thompson, 1809-1900, lawyer, judge, Indiana state legislator, U.S. congressman, U.S. secretary of navy.

The Dunn mss., 1834-1850, consists of the papers of George Grundy Dunn, 1812-1857, lawyer and congressman of Bedford, Indiana.

The Hughes mss., 1833-1888, are legal papers of the law firm of Hughes, Denver and Peck, Washington, D.C., largely consisting of Confederate and Native American claims before the U.S. Court of Claims.

The Dunn mss. II, 1831-1864, consists of the papers of George Grundy Dunn, 1812-1857, lawyer and congressman of Bedford, Indiana.

The Bicknell mss., 1828-1881, consist of the papers of George Augustus Bicknell, 1815-1891, of New Albany, Indiana, professor of law at Indiana University, 1861-1870, and a member of Congress from Indiana, 1877-1881.

The Dearborn County, Ind. mss., 1826-1871, consists of nine volumes of court dockets and miscellaneous papers related to the history of Dearborn County, Indiana.

The Spencer County, Indiana, History mss., 1822-1861, consist primarily of legal documents related to the history of Spencer County.

The Clay mss., 1812-1849, consists of a collection of political letters of congressman, U.S. senator, and secretary of state Henry Clay , 1777-1852.

The Lincoln mss., ca. 1798-1959, consist of letters, documents, and facsimile copies of documents by and about Abraham Lincoln, 1809-1865, his ancestors, immediate family, members of his cabinet, and other persons closely connected with him.

The Hall mss., 1797-1862, consists of the papers of Samuel Hall, 1797-1862, judge and member of the Board of Visitors of Indiana University.

The Judah mss., 1787-1927, consists of the papers of Samuel Judah, 1799-1869, lawyer of Vincennes, Indiana, and members of his family, particularly of his son, Samuel Brandon Judah, 1845-1928, stock raiser of Vincennes, Indiana.

The Niles mss., 1765-1916, are the law office papers and family correspondence of John Barron Niles, 1808-1879, lawyer of LaPorte, Indiana.

The Philippine mss. consist of original documents and transcripts relating to the Philippine Islands and the Spanish Roman Catholic missions in East Asia.