This collection is comprised of the personal papers of Andrew Wylie, Indiana University's first president and spans the period from 1808 to 1858, with the bulk of the records from 1828-1851. There are five record series within the collection. All series, except for the bill and receipts, are arranged and described at the item level. All of the material has been arranged in chronological order within its representative series. There are photocopies from other institutions scattered throughout the collection. Most of these photocopies were collected around the time of the compilation of Affectionately Yours: The Andrew Wylie Family Letters, 1828 to 1859, in 1995.

The first series, Jefferson and Washington College records, spans the period from 1814-1826, and contains documents created during Andrew Wylie's tenure as president of Jefferson College and Washington College. A topic prominently feature in the records is the attempted unification of both Jefferson and Washington Colleges. Included among the records in this series are minutes of Jefferson College faculty meetings written by Andrew Wyle, and a document written by Andrew Wylie describing the events resulting from the attempts to consolidate Washington and Jefferson Colleges into one institution. Many of the documents in this series are photocopies of originals housed at either the Washington and Jefferson College Archives or the Jefferson College Historical Society.

The second series is comprised of the personal correspondence to and from Andrew Wylie from the period 1815 to 1851. Included in this correspondence are numerous letters to and from William Holmes McGuffey, the prominent educator who created the McGuffey Readers, one of America's first textbooks. There are also numerous letters to and from family members, including most prominently his wife Margaret Ritchie Wylie, his sons Samuel Theophylact Wylie and John H. Wylie, and Samuel Brown Wylie. Other correspondents prominently featured in this series include John W. Scott and Henry A. Wise. This series also includes typescripts of some of Andrew Wylie's letters that were reprinted in Affectionately Yours: The Andrew Wylie Family Letters, 1828 to 1859, a 1995 publication by the staff of the Wylie House Museum. For correspondence concerning Wylie's official duties as president please refer to Collection C207.

The sermons, lectures, and writings of Andrew Wylie make up the third series, and span the period from 1822 to 1851. The sermons and lectures represented here primarily deal with Wylie's activities outside of his role as president of the university. Prominent among the records within this series are sermons and lectures on a variety of religious topics delivered primarily to audiences in Bloomington, Indianapolis or other sites in Indiana. The series also include three sets of compilations of Andrew Wylie's lectures on metaphysics and moral philosophy. For Wylie's presidential addresses and speeches please refer to Collection C207.

The fourth series, Bills and receipts, covers the period from 1808 to 1846, and primarily documents the expenditures incurred during the construction of Wylie House and the running of the household once construction was completed. This series is arranged chronologically, and is the only series in the collection that is not arranged and described at the item level.

The Biographical records about Andrew Wylie series spans the period from 1825 to 1858, and contains biographical sketches of Andrew Wylie or documents which relate to various events in his life. Included in this series are the eulogy given by William Daly at the funeral of Andrew Wylie, various resolutions or condolences written after the death of Andrew Wylie, and Andrew Wylie's final will and testament.