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Andrew Wylie assumed the position as the first president of Indiana College in 1829, and he died on 11 November 1851 of pneumonia which he developed after accidentally cutting his leg while chopping wood. This collection consists of Andrew Wylie's personal papers, and includes records documenting Wylie's tenure at Jefferson and Washington Colleges; correspondence with family and professional colleagues; Wylie's sermons, lectures, and writings; bills, contracts, and receipts relating primarily to building and maintaining the family residence; and biographical information on Wylie.

Andrew Wylie assumed the position as the first president of Indiana College in 1829. He died on 11 November 1851 of pneumonia, which he developed after accidentally cutting his leg while chopping wood. The collection is comprised of correspondence files, speeches, and administrative files from Wylie's presidential tenure.

Theophilus A. Wylie was the cousin of Indiana University's first president Andrew Wylie and spent most of his adult life at IU, beginning in 1836,serving as its librarian, professor, vice president, and at one point, its interim president. Collection consists of Wylie's correspondence, diaries, sermons, drawings, and writings.