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The U.S. History mss., 1612-1977, consist of individual items acquired separately either as a gift, purchase, transfer, or removal from a variety of sources, relating to the United States. Additions continue to be made.

The Indiana History mss., 1725-1973, consists of individual items related to the history of the state of Indiana, acquired separately either as a gift, purchase, transfer, or removal from a variety of sources.

The Holland mss., 1781-1953, consists of correspondence and papers of three generations of Holland family physicians from Bloomington, Indiana: Philip Calphy Holland, 1840-1929, his son, George Frank Holland, 1871-1936, and his son, Philip Todd Holland, 1905-1973.

The Kimball mss., 1828-1908, consists of the letters and papers of physician and soldier Nathan Kimball, 1822-1898.

The Tuttle mss., 1838-1912, are papers of Elizabeth A. Tuttle, 1823?-1896, nurse and teacher of Colebrook, Ohio, and of Ira Norris Noland, 1844?- , physician, who married Hattie Tuttle, niece of Elizabeth A. Tuttle.

The Bryan mss., 1849-1863, are chiefly the letters of George Washington Bryan, 1825-1893, physician, exchanged with his wife, Alice (Calhoun) Bryan, during his period of service in 1862-63 with the Union forces along the Mississippi River on the steamers Glasgow, the Tigress, the P. J. Pringle, and at Young's Point, Louisiana.

The Rogers mss., 1851-1878, consist of manuscripts of Joseph Goodwin Rogers, 1841-1908, Indiana physician.

The Wilder mss., 1860-1868, consist of letters to Edson Adelman Wilder, 1845-1927, hardware merchant of Orland, Indiana, from his friends and relatives serving in the 100th regiment, Co. B., of the Indiana Infantry.