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The Tuttle mss., 1838-1912, are papers of Elizabeth A. Tuttle, 1823?-1896, nurse and teacher of Colebrook, Ohio, and of Ira Norris Noland, 1844?- , physician, who married Hattie Tuttle, niece of Elizabeth A. Tuttle.

The Smith, H.W. mss., 1817-1987, consists of the letters of reformer Hannah Whitall Smith, 1832-1911, her daughters, art historian Mary Berenson, 1864-1945, and relief organizer Alys Whitall Pearsall Russell, 1867-1951, and her granddaughters, suffragist Ray Strachey, 1887-1940, and psychologist Karin Stephen, 1889–1953.

The McWhirter, Mrs. F.T. mss., 1840-1979, are papers of Luella Frances (Smith) McWhirter (Mrs. Felix Tony McWhirter), 1859-1952, clubwoman.

The Holland mss., 1781-1953, consists of correspondence and papers of three generations of Holland family physicians from Bloomington, Indiana: Philip Calphy Holland, 1840-1929, his son, George Frank Holland, 1871-1936, and his son, Philip Todd Holland, 1905-1973.

The Griffith mss., 1831-1881, consists of the papers of physician Thomas Jefferson Griffith, 1837-1924, and his wife, physician Martha Hutchings Griffith, 1842-1923.

The Cookery mss., circa 1660–circa 1918, consists of bound and individual writings, often on the topic of cookery, of persons involved with cooking by practice or trade.

The Champ mss., 1836-1931, consists of the papers of Indiana physician, businessman, and postmaster George W. Champ, 1830-1905.

The Barnhart mss., 1813-1962, consists of the papers of history scholar John Donald Barnhart, 1895-1967.