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The Indianapolis Mapping and Geographic Infrastructure System (IMAGIS) project contains administrative documents used by the project team as it developed between 1987-1988.

The Department of Communication Studies Records include correspondence, course syllabi, minutes, reports, release forms, and speech night planning documents. The records cover the department, its professors, and related programs between 1970 to 2015.

The Indiana University School of Medicine emerged from a number of private, proprietary medical schools that existed in Indianapolis in the nineteenth and early-twentieth centuries. The most important of these private medical schools were the Medical College of Indiana and the College of Physicians and Surgeons, both of which operated in Indianapolis. In the first decade of the twentieth century efforts began to try to merge these private schools under the state universities then in Indiana, Purdue University and Indiana University. The merger of several medical schools under Purdue University was short-lived. In 1903 Indiana University established first year (classroom) medical studies at Bloomington, and in 1907 merged with the Medical College of Indiana and the remnant of the Purdue medical school to establish clinical instruction in Indianapolis. In subsequent years the School of Medicine was housed in Indianapolis on a large campus with several hospitals, clinical, and research facilities. First year medical studies were moved to Indianapolis by the 1950s.

This collection contains the records of the Indiana Higher Education Telecommunications Service (IHETS) and its related entities. IHETS arose from the passage of the Indiana Higher Education Telecommunications Act by the Indiana General Assembly on March 11, 1967. The service oversaw statewide telecommunications systems connecting university campuses and partner institutions, including voice, video, and data networks.

Purdue University began to offer technical training courses in Indianapolis during World War Two (1939-1945) in cooperation with a federal government program to prepare for wartime industrial production needs. Purdue's Indianapolis presence continued after the end of the war, at first cooperating with the Indiana University Extension Division in Indianapolis to offer liberal arts and social sciences courses to Purdue students, and later in developing its own general education coursework as well as deepening its engineering and sciences offerings. In the 1950s Purdue acquired property on East 38th Street in Indianapolis and in 1961 opened its new building there housing its Indianapolis Extension operation. With the creation of IUPUI in 1969 the East 38th Street campus continued to serve as a place for science and engineering classes until new buildings were completed downtown on the IUPUI campus.