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The Cookery mss., circa 1660–circa 1918, consists of bound and individual writings, often on the topic of cookery, of persons involved with cooking by practice or trade.

The Wilder mss., 1860-1868, consist of letters to Edson Adelman Wilder, 1845-1927, hardware merchant of Orland, Indiana, from his friends and relatives serving in the 100th regiment, Co. B., of the Indiana Infantry.

The Latin American mss. Peru, 1535-1929, consist of over 6500 documents which trace the historical, economic and social development of what is presently known as Peru, with lesser coverage of Argentina, Bolivia, Chile and Ecuador.

The Griffith mss., 1831-1881, consists of the papers of physician Thomas Jefferson Griffith, 1837-1924, and his wife, physician Martha Hutchings Griffith, 1842-1923.

​The Evans mss., 1833-1873, consists of papers of Henry B. Evans, -1847?, physician and surgeon, of Marion County, Ind., and his heirs.

The Houstoun mss., 1774-1799, consist of correspondence of Alexander Houstoun, ?-1784, physican, and correspondence of members of his family.

The U.S. History mss., 1612-1977, consist of individual items acquired separately either as a gift, purchase, transfer, or removal from a variety of sources, relating to the United States. Additions continue to be made.

The Latin American mss. --Mexico II, 1560-1940, consists of individual items acquired separately either as a gift, purchase, transfer, or removal from a variety of sources, complementing the materials in the Latin American mss. Mexico collection. Additions continue to be made.

The Medieval and Renaissance mss., 700-1600, consists of individual items acquired from time to time either as a gift or purchased from a variety of sources.

The Champ mss., 1836-1931, consists of the papers of Indiana physician, businessman, and postmaster George W. Champ, 1830-1905.