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The Yanez mss. collection consists of historical documents pertaining to Colonial Ecuador.

The Palafox mss., 1639-1658, consist of documents and correspondence signed by and related to Juan de Palafox y Mendoza, a major figure of the Mexican Colonial era.

The German mss., ca. 16th century-2004, consist of individually acquired letters, documents, and historical and literary manuscripts written in German, relating to the history, culture, and life of Germany.

The Medical mss., ca. 1720-1890, consists of manuscripts regarding medical procedures, treatises, records, etc. in French and Latin.

The Cammack mss. consists of letters and documents, 1823-1894, of the Cammack and Robinson families, Quakers in Indiana.

The James, J. mss., ca. 1835-1852, consists of letters, land inventories, and financial papers relating to Indiana land investments.

The Loughridge mss., 1864-1895, consists of the medical diaries and papers of Dr. James H. Loughridge, 1828-1895, of Rensselaer, Jasper County, Indiana.

The Custer mss., 1876-1933, consists of a copy of the Proceedings of the Court of Inquiry, January 13, 1879, in the case of Major Marcus A. Reno concerning his conduct at the Battle of the Little Big Horn River, 1876.

The Jennett mss., 1886-1979, consists of miscellaneous letters and manuscripts collected by rare book curator Matthew Jennett.

The Von Tress mss., 1916-1993, consists of photocopies of manuscripts, pictures, records, letters, and published articles drawn from a memory book of Edward Campbell Von Tress, 1899-1976, an alumnus of Indiana University who helped head the university's Memorial Fund as Alumni Secretary.