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The Scottish mss., 1500-1707, consists of materials concerned with the genealogies, history, letters, and writings of Scotland.

The Cleland mss., 1911-1946, consists of the papers of botanist Ralph Erskine Cleland, 1892-1971. They consist chiefly of correspondence with prominent scientists on Oenothera, evening primrose.

The Aristotle mss., 1603-1704, consists of commentaries on the works of Aristotle. At least half of the volumes concentrate on logic, but other subjects are covered as well, including physics and general philosophy.

The Moenkhaus mss., 1892-1918, consist primarily of the correspondence of zoologist William J. Moenkhaus, 1871-1947, former professor at Indiana University.

The Parkin mss., 1900-1928, are letters from Thomas Parkin, British ornithologist, from prominent ornithologists, artists, novelists, statesmen, playwrights and authors.

The Lesueur mss., 1819-1830, consist of eight letters to Charles Alexandre Lesueur, 1778-1846, artist and naturalist, and bills of lading for minerals shipped by or to Lesueur.

​The Eigenmann mss., 1851-1971, consists of the papers of Carl H. Eigenmann, 1863-1927, ichthyologist, and his wife, Rosa Smith Eigenmann, 1858-1947, ichthyologist.

​The Fernández Nodal mss., 16th cent.-1883, consists of the papers of José Fernández Nodal, a Peruvian scholar born in 1822.

The Medieval and Renaissance mss., 700-1600, consists of individual items acquired from time to time either as a gift or purchased from a variety of sources.

The Altenburg mss., 1946-1960, consists of the papers of geneticist Edgar Altenburg, 1888-1967.

The Bentley mss. II, 1890-1965, consists of the correspondence and writings of Arthur Fisher Bentley, 1870-1957, philosopher and author.

The Bentley mss., 1891-1968, consists of the correspondence and writings of author Arthur Fisher Bentley, 1870-1957.

The Blatchley mss., 1883-1940, consists of the papers of Willis Stanley Blatchley, 1859-1940, Indiana state geologist and naturalist.

The Kunz mss., 1885-1887, consist of letters from John Casper Branner, 1850-1922, professor of geology at Indiana University, to George Frederick Kunz, 1856-1932, mineralogist.

The Butler mss., 1835-1937, includes papers, 1877-1937, of Amos William Butler, 1860-1937, zoologist, anthropologist, and sociologist, and a few papers, 1835-1871, of his father, William Wallace Butler, 1810-1903, merchant and farmer.

The Cooper, K.W. mss., 1946-1959, consists of the correspondence of geneticists Kenneth W. Cooper and Hermann Joseph Muller. The topics covered include the mutual research of both relating to Drosophila, as well as research and teaching opportunities for respective colleagues.

The Cummins mss., 1888-1980 (Bulk 1930-1970), consists of the correspondence, personal papers, blueprints and drawings of Clessie Lyle Cummins, 1888-1968, automotive diesel engine developer and founder of Cummins Engine Company of Columbus, Indiana.

The Fleischmann mss., 1942-1950, consist of the correspondence between Herbert J. Fleischmann, a chemist connected with the General Hospital, Cincinnati, Ohio, and Albert Einstein, 1879-1955, theoretical physicist.

The Nelson's Encyclopedia mss., 1946-1947, consist of an article on penicillin by Sir Howard Florey, and several letters about the article between Florey, geneticist Hermann Muller, psychologist and Northwestern University president Walter Dill Scott, and science editor at Nelson's Encyclopedia Myron R. Kirsch.

The Gay-Lussac mss., circa 1844, consist of an autograph manuscript by chemist Joseph Louis Gay-Lussac, 1778-1850, on the chemistry of wine.